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Article

MEI4 variations drive female reproductive disorders via impaired oocyte abundance and developmental potential.

Journal of genetics and genomics = Yi chuan xue bao - 1 Apr 2026

Wang Yiyang, Qi Yu, Xu Keyan, Tang Shuyan, Tan Luyi, Xu Bingying, Wang Ying, Zhang Shuxian, Zou Yang, Gao Yuan, Zhang Chunmei, Liang Xin, Jiao Xue, Zhao Shidou, Zhao Han, Wang Shixuan, Qin Yingying, Guo Ting, Chen Zi-Jiang

Abstract excerpt

Meiotic DNA double-strand break (DSB) formation is pivotal for oocyte development, regulating both ovarian reserve and oocyte developmental potential. Mutations in DSB formation genes have been associated with premature ovarian insufficiency (POI) and adverse pregnancy outcomes in women. Whole exome sequencing in 1530 POI patients across two Chinese cohorts identifies loss-of-function variants in the DSB...

Read the complete abstract on PubMed

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Share to DNA Breaks, Double-Stranded
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

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Share to Oocytes

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Share to Primary Ovarian Insufficiency

Source

Identifiers

PMID: 41419020
DOI: 10.1016/j.jgg.2025.12.005

Genes

MEI4
HORMAD1
REC114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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