Back to search

Article

Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn’s Disease

2024-01-30

Abstract excerpt

<h4>Background and Aims</h4> We previously identified small molecules predicted to reverse an ileal gene signature for future Crohn’s Disease (CD) strictures. Here we used a new human intestinal organoid (HIO) model system containing macrophages to test a lead candidate, eicosatetraynoic acid (ETYA). <h4>Methods</h4> Induced pluripotent stem cell lines (iPSC) were derived from CD patients and differentiated into...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
52aac0c6-3d12-5e26-95fc-abb64efd0df0
DOI
10.1101/2024.01.30.577959
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn’s DiseaseDOI 10.1101/2024.01.30.577959
Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem CellsSemantic proximity
Ileal derived organoids from Crohn’s disease patients show unique transcriptomic and secretomic signaturesSemantic proximity
A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized TherapeuticsSemantic proximity
Mesenchymal stem cells ameliorate inflammation in an experimental model of Crohn’s disease via the mesenterySemantic proximity
A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.Semantic proximity
Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic SignaturesSemantic proximity
Development of a Personalized Intestinal Fibrosis Model Using Human Intestinal Organoids Derived From Induced Pluripotent Stem CellsSemantic proximity
Intestinal organoids in inflammatory bowel disease: advances, applications, and future directionsSemantic proximity
Development of a human primary gut-on-a-chip to model inflammatory processesSemantic proximity
Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissueSemantic proximity
Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial BarrierSemantic proximity
Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal OrganoidsSemantic proximity
Select a neighboring publication to make it the new centre.