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Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells

17 Dec 2024

Abstract excerpt

BACKGROUND & AIMS: Organs of the gastrointestinal tract contain tissue-resident immune cells that function during tissue development, homeostasis, and disease. However, most published human organoid model systems lack resident immune cells, thus limiting their potential as disease avatars. For example, human intestinal organoids (HIOs) derived from pluripotent stem cells contain epithelial and various mesenchymal...

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Cancer Cells and Metastasis
Immune cells in cancer
Pluripotent Stem Cells Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39701210
DOI: 10.1016/j.jcmgh.2024.101444

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