Collateral damage of NUDT15 deficiency in cancer provides a cancer pharmacogenetic therapeutic window with thiopurines

Abstract excerpt

Genome instability is a hallmark of cancer and are driven by mutations in oncogenes and tumor suppressor genes. Despite successes seen with select targeted therapeutics, this type of personalized medicine is only beneficial for a small subpopulation of cancer patients who have one of a few actionable genetic changes. Most tumors also contain hundreds of passenger mutations that offered no fitness advantage or disa...

Topics

Open a Topic to create a Post that cites this publication.

• Acute Lymphoblastic Leukemia research
• Asian People
• Hispanic or Latino
• Inflammatory Bowel Diseases
• Methyltransferases
• Mutation
• Pharmacogenomic Variants
• Pyrophosphatases

Identifiers and source

Literature Corpus work

52a9208a-ae71-5b2b-9ae1-5e20d4cfa14f

DOI

10.1101/2024.04.08.588560