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Article

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

17 Jun 2019

Abstract excerpt

Mutations in the macroautophagy/autophagy gene WDR45 cause β-propeller protein-associated neurodegeneration (BPAN); however the molecular and cellular mechanism of the disease process is largely unknown. Here we generated constitutive wdr45 knockout (KO) mice that displayed cognitive impairments, abnormal synaptic transmission and lesions in several brain regions. Immunohistochemistry analysis showed loss of...

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PMID: 31204559
DOI: 10.1080/15548627.2019.1630224

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