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Article

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).

The Journal of biological chemistry - 3 Nov 2017

Shibutani Shusaku, Okazaki Hana, Iwata Hiroyuki

Abstract excerpt

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of protein synthesis and potential target for modifying cellular metabolism in various conditions, including cancer and aging. mTORC1 activity is tightly regulated by the availability of extracellular amino acids, and previous studies have revealed that amino acids in the extracellular fluid are transported to the lysosomal lumen. There,...

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Identifiers

PMID: 28808055
DOI: 10.1074/jbc.M117.776443
PMCID: PMC5672031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).PMID 28808055Read ↗

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.Semantic proximity Read ↗

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