Article
mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes.
Molecular cell - 21 Nov 2024
Zwakenberg Susan, Westland Denise, van Es Robert M, Rehmann Holger, Anink Jasper, Ciapaite Jolita, Bosma Marjolein, Stelloo Ellen, Liv Nalan, Sobrevals Alcaraz Paula, Verhoeven-Duif Nanda M, Jans Judith J M, Vos Harmjan R, Aronica Eleonora, Zwartkruis Fried J T
Abstract excerpt
To stimulate cell growth, the protein kinase complex mTORC1 requires intracellular amino acids for activation. Amino-acid sufficiency is relayed to mTORC1 by Rag GTPases on lysosomes, where growth factor signaling enhances mTORC1 activity via the GTPase Rheb. In the absence of amino acids, GATOR1 inactivates the Rags, resulting in lysosomal detachment and inactivation of mTORC1. We demonstrate that in human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.