Article
The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH.
mBio - 1 Jan 2011
Vylkova Slavena, Carman Aaron J, Danhof Heather A, Collette John R, Zhou Huaijin, Lorenz Michael C
Abstract excerpt
UNLABELLED: pH homeostasis is critical for all organisms; in the fungal pathogen Candida albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that beyond adaptation, C. albicans actively neutralizes the environment from either acidic or alkaline pHs. Under acidic conditions, this species can raise the pH from 4 to >7 in less than 12 h, resulting in autoinduction of the...
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