Article

The local topological free energy of the SARS-CoV-2 Spike protein

2021-02-07

Abstract excerpt

The novel coronavirus SARS-CoV-2 infects human cells using a mechanism that involves binding and structural rearrangement of its spike protein. Understanding protein rearrangement and identifying specific residues where mutations affect protein rearrangement has attracted a lot of attention for drug development. We use a mathematical method introduced in [9] to associate a local topological/geometrical free energy...

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Literature Corpus work: 528eee0a-dc41-5750-b956-663511e3b20b
DOI: 10.1101/2021.02.06.430094

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