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Article

Conformational Behavior of SARS-Cov-2 Spike Protein Variants: Evolutionary Jumps in Sequence Reverberate in Structural Dynamic Differences.

Journal of chemical theory and computation - 11 Apr 2023

Triveri Alice, Casali Emanuele, Frasnetti Elena, Doria Filippo, Frigerio Francesco, Cinquini Fabrizio, Pavoni Silvia, Moroni Elisabetta, Marchetti Filippo, Serapian Stefano A, Colombo Giorgio

Abstract excerpt

SARS-CoV-2 has evolved rapidly in the first 3 years of pandemic diffusion. The initial evolution of the virus appeared to proceed through big jumps in sequence changes rather than through the stepwise accumulation of point mutations on already established variants. Here, we examine whether this nonlinear mutational process reverberates in variations of the conformational dynamics of the SARS-CoV-2 Spike protein...

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COVID-19
Diffusion
Mutation
Protein Binding
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 36926878
DOI: 10.1021/acs.jctc.3c00077
PMCID: PMC10029694

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