Article

Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in <i>Aspergillus fumigatus</i>

2018-05-01

Abstract excerpt

Azole resistance in Aspergillus fumigatus is predominantly associated with increased expression of Cyp51A (lanosterol 14α-demethylase), the target enzyme of azole antifungal agents, or with single-nucleotide polymorphisms (SNPs) in cyp51A . Although several SNPs that may be linked to low susceptibility in azole-resistant isolates have previously been reported, few studies have been conducted to conclusively demo...

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Literature Corpus work: 52762dd5-567f-50a1-bf08-97190736d460
DOI: 10.1101/311712

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