Article
Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance.
Antimicrobial agents and chemotherapy - 1 Jan 2017
Wei Xiaolei, Chen Peiying, Gao Rongsui, Li Yeqi, Zhang Anxue, Liu Feifei, Lu Ling
Abstract excerpt
The rapid and global emergence of azole resistance in the human pathogen Aspergillus fumigatus has drawn attention. Thus, a thorough understanding of its mechanisms of drug resistance requires extensive exploration. In this study, we found that the loss of the putative calcium-dependent protein-encoding gene algA causes an increased frequency of azole-resistant A. fumigatus isolates. In contrast to previously...
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