Article

Cataract-associated deamidations on the surface of γS-crystallin increase protein unfolding and flexibility at distant regions

2019-05-22

Abstract excerpt

Deamidation is a major age-related modification in the human lens that is highly prevalent in crystallins isolated from cataractous lenses. However, the mechanism by which deamidation causes proteins to become insoluble is not known, because of only subtle structural changes observed in vitro . We have identified Asn14 and Asn76 of γS-crystallin as highly deamidated in insoluble proteins. These sites are on the s...

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Literature Corpus work: 5275a4ea-36f5-5269-b0a4-15b870e388fc
DOI: 10.1101/646083

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