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Article

Increased hydrophobic surface exposure in the cataract-related G18V variant of human γS-crystallin.

Biochimica et biophysica acta - 1 Jan 2016

Khago Domarin, Wong Eric K, Kingsley Carolyn N, Freites J Alfredo, Tobias Douglas J, Martin Rachel W

Abstract excerpt

BACKGROUND: The objective of this study was to determine whether the cataract-related G18V variant of human γS-crystallin has increased exposure of hydrophobic residues that could explain its aggregation propensity and/or recognition by αB-crystallin. METHODS: We used an ANS fluorescence assay and NMR chemical shift perturbation to experimentally probe exposed hydrophobic surfaces. These results were compared to...

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Identifiers

PMID: 26459004
DOI: 10.1016/j.bbagen.2015.09.022
PMCID: PMC5942885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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