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Article

Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency.

Nature medicine - 1 Nov 2009

Liang Yu, Vogel Jodi L, Narayanan Aarthi, Peng Hua, Kristie Thomas M

Abstract excerpt

Reversible methylation of histone tails serves as either a positive signal recognized by transcriptional assemblies or a negative signal that result in repression. Invading viral pathogens that depend upon the host cell's transcriptional apparatus are also subject to the regulatory impact of chromatin assembly and modifications. Here we show that infection by the alpha-herpesviruses, herpes simplex virus (HSV)...

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Identifiers

PMID: 19855399
DOI: 10.1038/nm.2051
PMCID: PMC2783573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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