Article

Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockade

2023-11-07

Abstract excerpt

<h4>Background: </h4> Fibrolamellar carcinoma (FLC) is a rare liver tumor driven by the DNAJ-PKAc fusion protein that affects healthy young patients. Little is known about the immune response to FLC, limiting rational design of immunotherapy. <h4>Methods: </h4>: Multiplex immunohistochemistry and gene expression profiling were performed to characterize the FLC tumor immune microenvironment and adjacent non-tumor...

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Literature Corpus work: 6a6ad390-261b-5960-8da3-b2f63f2370cd
DOI: 10.21203/rs.3.rs-3495912/v1

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