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Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia

27 Jan 2020

Abstract excerpt

Acute myeloid leukemia (AML) is a genetically heterogeneous disease that is characterized by abnormal clonal proliferation of myeloid progenitor cells found predominantly within the bone marrow (BM) and blood. Recent studies suggest that genetic and phenotypic alterations in the BM microenvironment support leukemogenesis and allow leukemic cells to survive and evade chemotherapy-induced death. However, despite...

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PMID: 31985806
DOI: 10.1182/bloodadvances.2019001124

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