Article

Transfer of antigen-encoding bone marrow under immune-preserving conditions deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

2019-12-21

Abstract excerpt

<h4>Summary</h4> Pathological activation and collaboration of T and B cells underlies pathogenic autoantibody responses. Existing treatments for autoimmune disease cause non-specific immunosuppression and induction of antigen-specific tolerance remains an elusive goal. Many immunotherapies aim to manipulate the T-cell component of T-B interplay but few directly target B cells. One possible means to specifically t...

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Literature Corpus work: 521988c9-6be8-5b0b-bd14-7194877a8d07
DOI: 10.1101/2019.12.20.885343

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