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Article

IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012

Dougan Stephanie K, Ogata Souichi, Hu Chih-Chi Andrew, Grotenbreg Gijsbert M, Guillen Eduardo, Jaenisch Rudolf, Ploegh Hidde L

Abstract excerpt

We used somatic cell nuclear transfer (SCNT) to generate a mouse from the nucleus of an IgG1(+) ovalbumin-specific B cell. The resulting OBI mice show generally normal B-cell development, with elevated percentages of marginal zone B cells and a reduction in B-1 B cells. Whereas OBI RAG1(-/-) mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22869725
DOI: 10.1073/pnas.1210273109
PMCID: PMC3427072

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22869725-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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