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Article

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer.

The Journal of experimental medicine - 6 Jul 2009

Koble Christian, Kyewski Bruno

Abstract excerpt

Central tolerance is shaped by the array of self-antigens expressed and presented by various types of thymic antigen-presenting cells (APCs). Depending on the overall signal quality and/or quantity delivered in these interactions, self-reactive thymocytes either apoptose or commit to the T regula...

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Source

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Identifiers

PMID: 19564355
DOI: 10.1084/jem.20082449
PMCID: PMC2715082

Genes

APC
TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19564355-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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