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The rs1421085 variant within <i>FTO</i> promotes but not inhibits thermogenesis and is potentially associated with human migration

2021-08-15

Abstract excerpt

<h4>Summary</h4> Disease-associated GWAS loci are predominantly scattered among noncoding regions of the human genome, which impedes causality estimation. One lead risk signal of obesity–rs1421085 T>C within the FTO gene–is reported to functional in vitro but lack of organismal evidence. Here, we established global and the brown-adipocyte specific locus-knock-in mice to recapitulate this homologous variant in h...

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Literature Corpus work
5214a3ac-b445-5d86-b39d-772be030f18a
DOI
10.1101/2021.08.13.456245
Open publication

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The rs1421085 variant within <i>FTO</i> promotes but not inhibits thermogenesis and is potentially associated with human migrationDOI 10.1101/2021.08.13.456245
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