Article

The rs1421085 variant within FTO promotes thermogenesis and is associated with human migration

2021-10-04

Abstract excerpt

<title>Abstract</title> <p>One lead risk signal of obesity–rs1421085 T > C within the <italic>FTO</italic> gene–is reported to be functional <italic>in vitro</italic> but lack of organismal evidence. Here, we established global and the brown-adipocyte specific locus-knock-in mice to recapitulate this homologous variant in humans and discovered that mice carrying the C-alleles showed increased thermogenic capacity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16aa5b5a-bf41-52e7-b92a-53873c6f3fe2
DOI: 10.21203/rs.3.rs-936477/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The rs1421085 variant within FTO promotes thermogenesis and is associated with human migrationDOI 10.21203/rs.3.rs-936477/v1Read

The rs1421085 variant within <i>FTO</i> promotes but not inhibits thermogenesis and is potentially associated with human migrationSemantic proximity Read

The bigger picture of FTO: the first GWAS-identified obesity gene.Semantic proximity Read

The genetics of obesity: FTO leads the way.Semantic proximity Read

FTO: the first gene contributing to common forms of human obesity.Semantic proximity Read

The composite alliance of FTO locus with obesity-related genetic variants.Semantic proximity Read

Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.Semantic proximity Read

FTO and obesity: a problem for a billion people.Semantic proximity Read

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.Semantic proximity Read

Human Abdominal Subcutaneous-Derived Active Beige Adipocytes Carrying <i>FTO</i> rs1421085 Obesity-Risk Alleles Exert Lower Thermogenic CapacitySemantic proximity Read

The role of FTO variant rs1421085 in the relationship with obesity: a systematic review and meta-analysis.Semantic proximity Read

Complex Relationship between Obesity and the Fat Mass and Obesity Locus.Semantic proximity Read

Variation in FTO contributes to childhood obesity and severe adult obesity.Semantic proximity Read