Article

Identification of a weight loss-associated causal eQTL in <i>MTIF3</i> and the effects of <i>MTIF3</i> deficiency on human adipocyte function

2022-10-17

Abstract excerpt

<h4>Background</h4> Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. <h4>Methods</h4> Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functio...

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Literature Corpus work: 9e39b51c-5192-548e-bae6-6ef386524218
DOI: 10.1101/2022.10.16.512435

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