Article

GBA1 status and sex impact on depression severity and progression in Parkinson’s Disease

2025-11-06

Abstract excerpt

<title>Abstract</title> <p>GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex impact occurrence and progression of depression. REM sleep behavior disorder predicted depression in GBA-PD, while sex, cognition, and motor complications were key predictors in nonGBA-PD. Depr...

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Literature Corpus work: 548f83aa-c7f1-5d01-81b1-d27b8cdaaf4d
DOI: 10.21203/rs.3.rs-7929738/v1

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