Article

Combined detrimental effect of male sex and GBA1 variants on cognitive decline in Parkinson’s Disease

2024-04-03

Abstract excerpt

<h4>Background and Objective</h4> Heterozygous variants in the glucocerebrosidase gene ( GBA1 ) are the major genetic risk factor for Parkinson’s Disease (PD). GBA-PD has been associated with worse progression and higher risk of cognitive decline. Here we took advantage of the Parkinson’s Progression Markers Initiative (PPMI) to investigate whether sex could interact with GBA1 carrier status in determining the cli...

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Literature Corpus work: 3611c1b5-6194-5d5a-87a9-7ab397a0268d
DOI: 10.1101/2024.04.02.24305191

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