Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury.

doi:10.1158/0008-5472.CAN-20-1010

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Article

Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury.

Cancer research - 1 Feb 2021

Hu Yi, Yang Chun, Amorim Tania, Maqbool Mohsin, Lin Jenny, Li Chen, Fang Chuanfeng, Xue Li, Kwart Ariel, Fang Hua, Yin Mei, Janocha Allison J, Tsuchimoto Daisuke, Nakabeppu Yusaku, Jiang Xiaofeng, Mejia-Garcia Alex, Anwer Faiz, Khouri Jack, Qi Xin, Zheng Qing Y, Yu Jennifer S, Yan Shan, LaFramboise Thomas, Anderson Kenneth C, Herlitz Leal C, Munshi Nikhil C, Lin Jianhong, Zhao Jianjun

Abstract excerpt

Cisplatin chemotherapy is standard care for many cancers but is toxic to the kidneys. How this toxicity occurs is uncertain. In this study, we identified apurinic/apyrimidinic endonuclease 2 (APE2) as a critical molecule upregulated in the proximal tubule cells (PTC) following cisplatin-induced nuclear DNA and mitochondrial DNA damage in cisplatin-treated C57B6J mice. The APE2 transgenic mouse phenotype...

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Identifiers

PMID: 33288657
DOI: 10.1158/0008-5472.CAN-20-1010
PMCID: PMC7869671

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