Article

A Globally Representative Immunopeptidomics Approach to Identify Population-Wide Vaccine Candidates

2025-11-26

Abstract excerpt

Vaccine development has historically relied on preclinical testing using one or two cell lines, typically of Caucasian descent, contributing to vaccines that may fail to provide adequate protection across genetically diverse populations. A major factor in these failures is the lack of consideration for human leukocyte antigen (HLA) diversity, with over 30,000 HLA alleles worldwide exhibiting distinct frequencies a...

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Literature Corpus work: 0c4f110c-3932-5565-b627-23953e73f5bc
DOI: 10.1101/2025.11.25.690604

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