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Article

Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2018

Singh Toolika, Fakiola Michaela, Oommen Joyce, Singh Akhil Pratap, Singh Abhishek K, Smith Noel, Chakravarty Jaya, Sundar Shyam, Blackwell Jenefer M

Abstract excerpt

HLA-DRB1 is the major genetic risk factor for visceral leishmaniasis (VL). We used SNP2HLA to impute HLA-DRB1 alleles and SNPTEST to carry out association analyses in 889 human cases and 977 controls from India. NetMHCIIpan 2.1 was used to map epitopes and binding affinities across 49 Leishmania vaccine candidates, as well as across peptide epitopes captured from dendritic cells treated with crude Leishmania Ag...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29507109
DOI: 10.4049/jimmunol.1701764
PMCID: PMC5893436

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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