Article

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

2020-09-11

Abstract excerpt

<h4>Summary</h4> Drugs that block the activity of the methyltransferase EZH2 are in clinical development for the treatment of non-Hodgkin lymphomas harboring gain-of-function EZH2 mutations that enhance its polycomb repressive function. In contrast, in castration-resistant prostate cancer (CRPC) we have previously reported that EZH2 plays a non-canonical role as a transcriptional activator. In this setting, we no...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51bc5778-54a9-5888-80c9-fadadbc4c2a8
DOI: 10.1101/2020.09.11.291534

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stressDOI 10.1101/2020.09.11.291534Read

Targeting EZH2 in cancer.Semantic proximity Read

Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutationsSemantic proximity Read

EZH2-associated tumor malignancy: A prominent target for cancer treatment.Semantic proximity Read

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformationSemantic proximity Read

Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations.Semantic proximity Read

EZH2-Deficient T-cell Acute Lymphoblastic Leukemia Is Sensitized to CHK1 Inhibition through Enhanced Replication Stress.Semantic proximity Read

EZH2 inhibition enhances the activity of platinum chemotherapy in aggressive-variant prostate cancerSemantic proximity Read

Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor TypesSemantic proximity Read

Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.Semantic proximity Read

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant promoting oncogene activation and tumorous transformationSemantic proximity Read

The polycomb group protein EZH2 is involved in progression of prostate cancer.Semantic proximity Read

Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemiaSemantic proximity Read