Article

Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations

2023-11-21

Abstract excerpt

Epigenetic regulators such as the polycomb repressive complex 2 (PRC2) play a critical role in both normal development and carcinogenesis. Mutations and functional dysregulation of PRC2 complex components such as EZH2 are implicated in various forms of cancer and associated with poor prognosis. This study investigated the epigenetic vulnerabilities of acute myeloid leukemia (AML) and myelodysplastic/myeloprolifera...

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Literature Corpus work: 6846ba16-6da3-5571-b13d-69edce335b65
DOI: 10.1101/2023.11.20.567858

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