Article
Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations.
Experimental hematology - 1 Feb 2024
Alqazzaz Mona A, Luciani Genna M, Vu Victoria, Machado Raquel A C, Szewczyk Magdalena M, Adamson Ella C, Cheon Sehyun, Li Fengling, Arrowsmith Cheryl H, Minden Mark D, Barsyte-Lovejoy Dalia
Abstract excerpt
Epigenetic regulators, such as the polycomb repressive complex 2 (PRC2), play a critical role in both normal development and carcinogenesis. Mutations and functional dysregulation of PRC2 complex components, such as EZH2, are implicated in various forms of cancer and associated with poor prognosis. This study investigated the epigenetic vulnerabilities of acute myeloid leukemia (AML) and...
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