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Update on the hyper immunoglobulin M syndromes

23 Feb 2010

Abstract excerpt

The Hyper-immunoglobulin M syndromes (HIGM) are a heterogeneous group of genetic disorders resulting in defects of immunoglobulin class switch recombination (CSR), with or without defects of somatic hypermutation (SHM). They can be classified as defects of signalling through CD40 causing both a humoral immunodeficiency and a susceptibility to opportunistic infections, or intrinsic defects in B cells of the...

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PMID: 20180797
DOI: 10.1111/j.1365-2141.2010.08077.x

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