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Article

Hyper immunoglobulin M syndrome due to CD40 deficiency: clinical, molecular, and immunological features.

Immunological reviews - 1 Feb 2005

Lougaris Vassilios, Badolato Raffaele, Ferrari Simona, Plebani Alessandro

Abstract excerpt

CD40 is a member of the tumor necrosis factor receptor family, which is expressed by a variety of cells including B cells, macrophages, dendritic cells, and other nonimmune cell types. CD40 activation is critical for B-cell proliferation, immunoglobulin (Ig)-isotype switching, and germinal center formation. In physiological conditions, the activation of CD40 occurs by binding to its natural ligand, CD154, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15661021
DOI: 10.1111/j.0105-2896.2005.00229.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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