Small heat shock proteins in neurodegenerative diseases.

doi:10.1007/s12192-020-01101-4

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Article

Small heat shock proteins in neurodegenerative diseases.

Cell stress & chaperones - 1 Jul 2020

Vendredy Leen, Adriaenssens Elias, Timmerman Vincent

Abstract excerpt

Small heat shock proteins are ubiquitously expressed chaperones, yet mutations in some of them cause tissue-specific diseases. Here, we will discuss how small heat shock proteins give rise to neurodegenerative disorders themselves while we will also highlight how these proteins can fulfil protective functions in neurodegenerative disorders caused by protein aggregation. The first half of this paper will be...

Topics

Alzheimer Disease
Charcot-Marie-Tooth Disease
Heat-Shock Proteins
Heat-Shock Proteins, Small
Humans
Huntington Disease
Molecular Chaperones
Mutation
Parkinson Disease

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Identifiers

PMID: 32323160
DOI: 10.1007/s12192-020-01101-4
PMCID: PMC7332613

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