Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias.

Cerebellum (London, England) - 1 Jan 2007

Huen N Y Macy, Wong S L Alan, Chan H Y Edwin

Abstract excerpt

Among the various dominantly-inherited spinocerebellar ataxias (SCAs), at least seven of them belong to the polyglutamine disease group and are caused by glutamine-coding CAG triplet repeat expansion. The expanded coding CAG repeat translates into a polyglutamine stretch in the disease protein, which leads to late-onset and progressive neurodegeneration. Expanded polyglutamine adopts a misfolded protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation
Share to Heat-Shock Proteins
Share to Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Folding

Share to Spinocerebellar Ataxias

Share to Stress, Physiological

Share to Transcription, Genetic

Share to Trinucleotide Repeat Expansion

Source

Identifiers

PMID: 17510910
DOI: 10.1080/14734220600996480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias.PMID 17510910Read ↗

Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human NeuronsSemantic proximity Read ↗

Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseasesSemantic proximity Read ↗

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.Semantic proximity Read ↗

Activation of Gene Transcription by Heat Shock Protein 27 May Contribute to Its Neuronal ProtectionSemantic proximity Read ↗

[Neurodegenerative conformational disease and heat shock proteins].Semantic proximity Read ↗

Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunitiesSemantic proximity Read ↗

Induction of Molecular Chaperones as a Therapeutic Strategy for the Polyglutamine DiseasesSemantic proximity Read ↗

Knockdown of Heat Shock Proteins HSPA6 (Hsp70B’) and HSPA1A (Hsp70-1) Sensitizes Differentiated Human Neuronal Cells to Cellular StressSemantic proximity Read ↗

The heat shock response in neurons and astroglia and its role in neurodegenerative diseasesSemantic proximity Read ↗

Structure, function, property, and role in neurologic diseases and other diseases of the sHsp22.Semantic proximity Read ↗

The family of mammalian small heat shock proteins (HSPBs): implications in protein deposit diseases and motor neuropathies.Semantic proximity Read ↗

Whole genome transcriptomic reveals heat stroke molecular signatures in humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.