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Article

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis.

Cancer research - 1 Oct 2015

Riesco-Eizaguirre Garcilaso, Wert-Lamas León, Perales-Patón Javier, Sastre-Perona Ana, Fernández Lara P, Santisteban Pilar

Abstract excerpt

The presence of differentiated thyroid cells in thyroid cancer is critical for the antitumor response to radioactive iodide treatment, and loss of the differentiated phenotype is a key hallmark of iodide-refractory metastatic disease. The role of microRNAs (miRNA) in fine-tuning gene expression has become a major regulatory mechanism by which developmental and pathologic processes occur. In this study, we...

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PMID: 26282166
DOI: 10.1158/0008-5472.CAN-14-3547

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PAX8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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