Article

Effect of Aging, Sex, and Gene (Fbln5) on Arterial Stiffness of Mice: 20 Weeks Adult Fbln5-knockout Mice Have Older Arteries than 100 Weeks Wild-Type Mice

2023-06-01

Abstract excerpt

The arterial stiffening is a strong independent predictor of cardiovascular risk and has been used to characterize the biological age of arteries (‘arterial age’). Here we revealed that the Fbln5 gene knockout (Fbln5 -/- ) significantly increases the arterial stiffening for both male and female mice. We also showed that the arterial stiffening increases with natural aging, but the stiffening effect of Fbln5 -/-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51857f9e-ca89-5f9a-825f-c6e7a178a8e8
DOI: 10.1101/2023.05.30.542920

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effect of Aging, Sex, and Gene (Fbln5) on Arterial Stiffness of Mice: 20 Weeks Adult Fbln5-knockout Mice Have Older Arteries than 100 Weeks Wild-Type MiceDOI 10.1101/2023.05.30.542920Read

Elastin haploinsufficiency in mice has divergent effects on arterial remodeling with aging depending on sexSemantic proximity Read

In vivo phenotypic vascular dysfunction extends beyond the aorta in a mouse model for fibrillin-1 (Fbn1) mutation.Semantic proximity Read

Elastin, arterial mechanics, and cardiovascular diseaseSemantic proximity Read

<i>In Vivo</i> Phenotypic Vascular Dysfunction Extends Beyond the Aorta in a Mouse Model for Fibrillin-1 ( <i>FBN1</i> ) MutationSemantic proximity Read

Unraveling the Sex-Dependent Relationship Between Central, Peripheral and Cerebral Arteries Function in a Mouse Model of Marfan Syndrome: Benefits of Exercise Training on Vascular Function and Blood FlowSemantic proximity Read

Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.Semantic proximity Read

Biomechanical phenotyping of central arteries in health and disease: advantages of and methods for murine models.Semantic proximity Read

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary AgingSemantic proximity Read

Decreased elastic energy storage, not increased material stiffness, characterizes central artery dysfunction in fibulin-5 deficiency independent of sex.Semantic proximity Read

Unraveling Elastic Fiber-Derived Signaling in Arterial Aging and Related Arterial DiseasesSemantic proximity Read

Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during agingSemantic proximity Read

Mechanical factors direct mouse aortic remodelling during early maturation.Semantic proximity Read