Article

<i>In Vivo</i> Phenotypic Vascular Dysfunction Extends Beyond the Aorta in a Mouse Model for Fibrillin-1 ( <i>FBN1</i> ) Mutation

2023-11-18

Abstract excerpt

In individuals with Marfan Syndrome (MFS), fibrillin-1 gene ( FBN1 ) mutations can lead to vascular wall weakening and dysfunction. The experimental mouse model of MFS ( FBN1 C1041G/+ ) has been advantageous in investigating MFS-associated life-threatening aortic aneurysms. Although the MFS mouse model presents an accelerated-aging phenotype in elastic organs (e.g., lung, skin), the impact of FBN1 mutations on...

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Literature Corpus work: f5b903fb-0aa9-5f11-9bab-8212b521289f
DOI: 10.1101/2023.11.18.567641

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