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Article

Enrichment of T: A→A: T substitutions in the TP53 gene in esophageal carcinoma with high Fusobacterium burden.

Scientific reports - 10 Apr 2026

Tahara Tomomitsu, Shijimaya Takuya, Yamazaki Jumpei, Shimogama Tsubasa, Kobayashi Sanshiro, Nakamura Naohiro, Takahashi Yu, Tomiyama Takashi, Fukui Toshiro, Shibata Tomoyuki, Naganuma Makoto

Abstract excerpt

Exogenous lifestyle and environmental risk factors impact mutation burden in both benign and cancerous tissues. Moreover, interactions between the mucosa-associated microbiome and such genotoxic changes have been implicated in several cancer types. This study aimed to characterize the TP53 mutation spectrum in esophageal carcinoma (EC) with high amounts of Fusobacterium species. Quantitative PCR analysis of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41963410
DOI: 10.1038/s41598-026-45806-5
PMCID: PMC13199510

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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