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Expansion of a bacterial operon during cancer treatment ameliorates fluoropyrimidine toxicity

16 Apr 2025

Abstract excerpt

Dose-limiting toxicities remain a major barrier to drug development and therapy, revealing the limited predictive power of human genetics. Here, we demonstrate the utility of a more comprehensive approach to studying drug toxicity through longitudinal profiling of the human gut microbiome during colorectal cancer (CRC) treatment (NCT04054908) coupled to cell culture and mouse experiments. Substantial shifts in...

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PMID: 40238917
DOI: 10.1126/scitranslmed.adq8870

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