Article

Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity

2024-06-06

Abstract excerpt

Dose-limiting toxicities remain a major barrier to drug development and therapy, revealing the limited predictive power of human genetics. Herein, we demonstrate the utility of a more comprehensive approach to studying drug toxicity through longitudinal study of the human gut microbiome during colorectal cancer (CRC) treatment ( NCT04054908 ) coupled to cell culture and mouse experiments. 16S rRNA gene sequencing...

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Literature Corpus work: 16de2967-a3da-5650-8aaf-9aca02f0fa24
DOI: 10.1101/2024.06.04.597471

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