Article

Identification of genes involved in reprogramming-induced senescence

2015-01-01

Abstract excerpt

Senescence is a state of irreversible growth arrest first described in human fibroblasts when they undergo serial passage in vitro. Senescence can also occur in response to different stresses, such as replicative exhaustion, DNA damage or overexpression of oncogenes. The growth arrest associated with senescence is implemented by the activation of the p53/p21Cip1 and p16INK4a/Rb pathways. The expression in somatic...

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Literature Corpus work: 40fe26cf-f34b-5380-ab43-491cc2148fd9
DOI: 10.25560/44980

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