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Article

Stellabody: A novel hexamer-promoting mutation for improved IgG potency.

Immunological reviews - 1 Nov 2024

Whitehead Clarissa A, Wines Bruce D, Davies Anna M, McDonnell James M, Trist Halina M, Esparon Sandra E, Hogarth P Mark

Abstract excerpt

Advances in antibody engineering are being directed at the development of next generation immunotherapeutics with improved potency. Hexamerisation of IgG is a normal physiological aspect of IgG biology and recently described mutations that facilitate this process have a substantial impact upon monoclonal antibody behavior resulting in the elicitation of dramatically enhanced complement-dependent cytotoxicity, Fc...

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Share to Antibodies, Bispecific
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Fc Fragments

Share to Immunoglobulin G

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Source

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Identifiers

PMID: 39364646
DOI: 10.1111/imr.13400
PMCID: PMC11659935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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