Article

Dual-Targeted Near-Infrared Photoimmunotherapy for Esophageal Cancer and Cancer-Associated Fibroblasts in the Tumor Microenvironment

2022-07-12

Abstract excerpt

Cancer-associated fibroblasts (CAFs) play a significant role in tumor progression within the tumor microenvironment. Previously, we used near-infrared photoimmunotherapy (NIR-PIT), a next-generation cancer cell-targeted phototherapy, to establish CAF-targeted NIR-PIT. In this study, we investigated whether dual-targeted NIR-PIT, targeting cancer cells and CAFs, could be a therapeutic strategy. A total of 132 cases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5136943a-ddd5-5766-8048-7291062f9e24
DOI: 10.21203/rs.3.rs-1367605/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual-Targeted Near-Infrared Photoimmunotherapy for Esophageal Cancer and Cancer-Associated Fibroblasts in the Tumor MicroenvironmentDOI 10.21203/rs.3.rs-1367605/v2Read

Cancer-associated fibroblasts induce epithelial-mesenchymal transition of esophageal squamous cell carcinoma through paracrine TGFβ1 signallingSemantic proximity Read

Cancer-associated fibroblasts: tumor defenders in radiation therapy.Semantic proximity Read

Theranostic Radiopharmaceuticals Targeting Cancer-Associated Fibroblasts.Semantic proximity Read

Identification and characterization of FGFR2+ hematopoietic stem cell-derived fibrocytes as precursors of cancer-associated fibroblasts induced by esophageal squamous cell carcinomaSemantic proximity Read

Targeted therapy in esophageal cancer.Semantic proximity Read

Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.Semantic proximity Read

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through AutophagySemantic proximity Read

Hematopoietic stem cell-derived fibrocytes as targets and tools for cancer therapy: mechanisms and therapeutic implicationsSemantic proximity Read

Potential of Gold Nanoparticles in Current Radiotherapy Using a Co-Culture Model of Cancer Cells and Cancer Associated FibroblastsSemantic proximity Read

Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancerSemantic proximity Read

CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors.Semantic proximity Read

α,1,6-Fucosyltransferase (FUT8) regulates cancer-promoting capacities of cancer-associated fibroblasts (CAFs) through the modification of EGFR core fucosylation in non-small cell lung cancerSemantic proximity Read