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Article

Cancer-associated fibroblasts: tumor defenders in radiation therapy.

Cell death & disease - 22 Aug 2023

Zhang Yalin, Lv Na, Li Manshi, Liu Ming, Wu Chunli

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment that are involved in multiple aspects of cancer progression and considered contributors to tumor immune escape. CAFs exhibit a unique radiation resistance phenotype, and can survive clinical radiation doses; however, ionizing radiation can induce changes in their secretions and influence tumor progression by acting on...

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Identifiers

PMID: 37607935
DOI: 10.1038/s41419-023-06060-z
PMCID: PMC10444767

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