Article

α,1,6-Fucosyltransferase (FUT8) regulates cancer-promoting capacities of cancer-associated fibroblasts (CAFs) through the modification of EGFR core fucosylation in non-small cell lung cancer

2019-12-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Cancer-associated fibroblasts (CAFs), the main component of the tumor microenvironment (TME) of NSCLC, are activated by phenotypic transformation into myofibroblasts. α,1,6-fucosyltransferase (FUT8), the key enzyme catalyzing core α,1,6-fucosylation (CF), plays important roles in multiple malignancies. In the current study, we investigated the functions and mechan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea76153e-9698-5f22-ab79-b6466501c49c
DOI: 10.21203/rs.2.18620/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

α,1,6-Fucosyltransferase (FUT8) regulates cancer-promoting capacities of cancer-associated fibroblasts (CAFs) through the modification of EGFR core fucosylation in non-small cell lung cancerDOI 10.21203/rs.2.18620/v1Read

Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non–Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell InvasionSemantic proximity Read

FUT8-mediated core fucosylation modulates growth-related functions of LRP1 in liver cancer cellsSemantic proximity Read

Fucosylated exosomal miRNAs as promising biomarkers for the diagnosis of early lung adenocarcinomaSemantic proximity Read

Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features.Semantic proximity Read

Cancer‐associated fibroblast migration in non‐small cell lung cancers is modulated by increased integrin α11 expressionSemantic proximity Read

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancerSemantic proximity Read

Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer <i>In Vivo</i>Semantic proximity Read

Hematopoietic stem cell-derived fibrocytes as targets and tools for cancer therapy: mechanisms and therapeutic implicationsSemantic proximity Read

Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA SignalingSemantic proximity Read

Identification and characterization of FGFR2+ hematopoietic stem cell-derived fibrocytes as precursors of cancer-associated fibroblasts induced by esophageal squamous cell carcinomaSemantic proximity Read

Aberrant Fucosylation of Saliva Glycoprotein Defining Lung Adenocarcinomas MalignancySemantic proximity Read

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.Semantic proximity Read