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Article

Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jul 2024

Meng Xiaoyan, Liu Zhonglong, Deng Liang, Yang Yangzi, Zhu Yingchun, Sun Xiaoying, Hao Yongqiang, He Yue, Fu Jingke

Abstract excerpt

Tumor microenvironment (TME) plays an important role in the tumor progression. Among TME components, cancer-associated fibroblasts (CAFs) show multiple tumor-promoting effects and can induce tumor immune evasion and drug-resistance. Regulating CAFs can be a potential strategy to augment systemic anti-tumor immunity. Here, the study observes that hydrogen treatment can alleviate intracellular reactive oxygen...

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Identifiers

PMID: 38757665
DOI: 10.1002/advs.202401269
PMCID: PMC11267370

Genes

CD4

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