Article

Cancer-associated fibroblasts induce epithelial-mesenchymal transition of esophageal squamous cell carcinoma through paracrine TGFβ1 signalling

2022-09-01

Abstract excerpt

<h4>Background: </h4> Concurrent chemoradiotherapy is the standard treatment regimen for unresectable advanced patients with esophageal squamous cell carcinoma. CAFs (cancer-associated fibroblasts), one major component of tumor microenvironment were involved in tumor initiation and progression. However, the mechanisms by which CAFs enhanced the malignance of ESCC have remained most unknown. Epithelial-to-mesenchym...

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Literature Corpus work: 2d775704-1a7e-5b45-9589-1ff6a42caf21
DOI: 10.21203/rs.3.rs-1945707/v1

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