Article
CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors.
Scientific reports - 21 Apr 2017
Ishibashi Masayuki, Neri Shinya, Hashimoto Hiroko, Miyashita Tomoyuki, Yoshida Tatsuya, Nakamura Yuka, Udagawa Hibiki, Kirita Keisuke, Matsumoto Shingo, Umemura Shigeki, Yoh Kiyotaka, Niho Seiji, Tsuboi Masahiro, Masutomi Kenkichi, Goto Koichi, Ochiai Atsushi, Ishii Genichiro
Abstract excerpt
Cancer associated fibroblasts (CAFs) play important roles in the chemotherapeutic process, especially through influencing the resistance of tumor cells to molecular targeted therapy. Here we report the existence of a special subpopulation of patient-specific-CAFs that augment the sensitivity of EGFR gene mutation-positive lung cancer to the EGFR-tyrosine kinase inhibitor (EGFR-TKI), gefitinib. When cocultured...
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