Article

Glutamine is required for M1-like polarization in response to <i>Mycobacterium tuberculosis</i> infection

2022-01-11

Abstract excerpt

In response to Mycobacterium tuberculosis infection, macrophages mount early proinflammatory and antimicrobial responses similar to those observed in M1 macrophages classically activated by LPS and IFN-γ. A metabolic reprogramming to HIF-1-mediated uptake of glucose and its metabolism by glycolysis is required for M1-like polarization, but little is known about other metabolic programs driving M1-like polarizatio...

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Literature Corpus work: 51327eee-8233-5161-9e61-2cd973cd64a0
DOI: 10.1101/2022.01.11.475775

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